Hello List,
Speaking of needing mutations...
Member #145426, the descendant of Matthew Gillaspie CARRICO of Spencer Co., KY,
and Panola Co., TX, is a 67/67 match with the modal haplotype for the family.
In an effort to find some mutations, this individual has tested the most
variable of the advanced markers, namely, DYS720 and the Palindromic Pack:
http://dgmweb.net/genealogy/DNA/FTDNA-Markers-maxout.shtml
Two other members have tested DYS720: #94556, the descendant of John Alexander
CARRICO of Montgomery Co., MD, and, of course, #86809, the descendant of Abel,
who has maxed out his markers. All three have the same result: 33.2 (the
decimal fraction indicates the presence of a "microallele"), though only 12% of
people tested are 33.2 at this marker.
The Palindromic Pack includes three markers already tested among the standard
markers, namely: DYS413, DYS464, and DYS724, a.k.a., CDYa/b. It's cheaper to
test the entire panel than to cherry pick individual markers, so there's no
point in not allowing these markers to be re-tested. In fact, the DYS464x test
is an improved one that determines the allele for each copy, the possibilities
being either c (cytosine) or g (guanine). It turns out, all four DYS464 alleles
are guanine, sometimes indicated gggg or 0c4g. The order of the four alleles
remains unknown, so by convention they are, as before, reported lo-hi:
11g-12g-15g-16g.
Only two members have tested the Palindromic Pack, and it turns out the only
difference is at CDYb, a difference we were already aware of because it's also a
Standard marker:
http://dgmweb.net/genealogy/DNA/Carrico/CarricoDNA-results-HgJ2.shtml#Adv...
Of course, it's disappointing and frustrating that we did not pick up any
additional mutations. In my STRAUB project, where we have a similar situation,
with individuals matching 67/67, we picked up several mutations in the
Palindromic Pack. All I can suggest is that we keep trying. We are
sufficiently distant from Peter I that we should be picking up mutations if we
test enough markers. Unfortunately, mutations are truly random, so there's no
way to predict where they will be or who will have them... You don't know until
you test.
Diana