Hello List,
We have results back for the DYF371X palindromic set for both of our members who
ordered them. Their results match, which is expected, and would you guess...
their results are unique and unusual?!
9c-10t-10c-14c
The set consists of four markers, three of which are identified with a "c" base
and one with a "t." The t-allele, on its own, is marker DYS425. The normal,
almost universal, value for the t-allele is 12. Other values, namely, 11, 13,
or 14, are rare. Our CARRICOs appear to be the first individuals ever tested
who are 10t at this marker, at least according to Gareth Henson, a guru on the
topic, and based on the DNA-Fingerprint Ymatch database:
http://www.dna-fingerprint.com/modules.php?op=modload&name=ymatch
Our closest match in the Ymatch database is with another J2f (=J2a1b), whose
results are:
9c-12t-10c-14c
who retains the "normal" value of 12t.
I have also received an advanced notification that our fourth CARRICO, the one
whose grandfather was born in Portugal, is null for DYS425, so I have asked him
to take the DYF371X test to find out what is going on there.
A "null" value for DYS425 doesn't mean the marker is missing, it means the
"t"
allele is not there, so the DYS425 test fails. What has usually happened is a
RecLOH event (recombination loss of heterozygosity). In this case, the mutation
is not a simple gain or loss of a repeated segement, which would, for example,
change a 12t to a 13t, but a complete replacement of the t-allele by one of the
c-alleles. In other words, we might expect someone who tests null for DYS425 to
have these values on a DYF371X test:
10c-10c-13c-14c
The first c-allele has supplanted the t-allele causing a failure of the DYS425
test. In other cases, the t-allele can replace a c-allele in a process called
reverse copying, then subsequent gains or losses of repeats can further change
the values:
10c-12t-13t-14c
This condition (with two t-alleles) will produce two values for DYS425, but will
be reported as a "null" because the FTDNA database isn't currently set up
to
handle two values in the DYS425 field. null425 is generally rare, but common
enough that a project has been set up for this condition:
http://www.familytreedna.com/public/null425/
When actual results return for our fourth CARRICO, I urge him to join the
null425 project.
For those who have taken the DYF371X test, you will not find boxes at Ysearch to
enter these results. My suggestion is to add your results of this test (and the
*positive* results from your SNP tests) in the text box available for
"Additional" information. You will need to make these entries yourself
because,
while I have access to your member pages at the FTDNA web site, I cannot edit
your Ysearch page because doing so requires a password known only by you. If
you want me to make these modifications for you, you will need to send me your
password (via private email -- not on the list!).
In addition, for those taking any advanced tests, I recommend uploading them to
Ymatch (link above). DNA-Fingerprint is the company purchased by FTDNA last
year. They are the ones actually doing these advanced tests, and they are
obviously still maintaining the DNA-FP web site. I suspect at some point the
Ymatch database will be merged with the Ysearch database, but the programming
effort probably means it won't happen soon. So, at presnt, Ymatch is the
best/only place to upload advanced markers.
As always, a special thanks to those of you who have opted for the advance
testing. We seem to be breaking new ground with each test!
Diana